Added: Micholas Senecal - Date: 29.10.2021 22:55 - Views: 47607 - Clicks: 4042
Six healthy male volunteers were exposed to the vapor of and mg freebase cocaine heated to a temperature of degrees C in an unventilated room 12,L volume for a period of 1 h. No pharmacological effects were detected as a result of the exposure. Blood specimens collected immediately following exposure were negative for cocaine and metabolites. The peak excretion time for benzoylecgonine following passive exposure was approximately 5 h.
The amount of cocaine inhaled by the subjects during passive exposure was estimated from room air measurements of cocaine to be approximately 0. The total amount of cocaine cocaine plus metabolites excreted in urine by the six subjects ranged from 0. For comparison, the six subjects also received an intravenous injection of 1 mg cocaine hydrochloride. A second passive inhalation study was undertaken in which specimens were collected from research staff who assisted in a series of experimental studies with "crack" freebase cocaine smokers. The research staff remained in close vicinity while the crack smokers smoked three doses of freebase cocaine As a result, staff members were passively exposed to sidestream smoke from crack pipes and to breath exhalation from the crack smokers.
Overall, these studies demonstrated that individuals exposed to cocaine smoke under naturalistic or artificial conditions absorbed small amounts of cocaine that were insufficient to produce positive urine specimens at standard Department of Health and Human Services cutoffs. However, passive exposure conditions that would result in absorption of cocaine in amounts exceeding 1 mg could result in the production of cocaine-positive urine specimens. Please enable it to take advantage of the complete set of features!
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of items displayed: 5 10 15 20 50 Create RSS Cancel. RSS Link Copy. Full text links Cite Display options Display options. Abstract Six healthy male volunteers were exposed to the vapor of and mg freebase cocaine heated to a temperature of degrees C in an unventilated room 12,L volume for a period of 1 h. Similar articles Concentration profiles of cocaine, pyrolytic methyl ecgonidine and thirteen metabolites in human blood and urine: determination by gas chromatography-mass spectrometry. Paul BD, et al. Biomed Chromatogr. PMID: Comparison of heroin and cocaine concentrations in saliva with concentrations in blood and plasma.
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